New York, January 22, 2026, 20:16 EST — Market closed
Pfizer shares ended Thursday up 0.8%, closing at $26.10 after climbing Wednesday. The stock stayed comfortably within the mid-$20s, fluctuating between $25.75 and $26.31 during the session. 1
The move came as vaccine makers assessed rapid policy changes in the U.S. under Health Secretary Robert F. Kennedy Jr., a shift now creeping into investor talks and sector bets. “Vaccines will not be a growth area under the current administration,” said Stephen Farrelly, ING’s global pharma and healthcare lead. Pfizer CEO Albert Bourla expressed being “seriously frustrated,” blaming the rhetoric for declining vaccination rates. 2
This week, Pfizer added a new twist to its vaccine tech portfolio. Novavax revealed a non-exclusive licensing deal granting Pfizer access to its Matrix‑M adjuvant, which amplifies immune response, for vaccines targeting up to two infectious diseases. Novavax will get $30 million upfront in Q1 and could pull in as much as $500 million from milestones and royalties. CEO John Jacobs noted interest in Matrix‑M has surged “multiples more.” 3
The policy shift is concrete. U.S. officials have reversed longstanding guidance on routine childhood vaccinations for influenza and several other illnesses, opting instead for “shared clinical-decision-making” — a more individualized approach where parents and clinicians decide together, rather than issuing a universal recommendation. 4
Pfizer is already grappling with shifting from pandemic-driven demand to fresh products and late-stage pipeline hopes. Back in December, the company flagged rough waters ahead as COVID sales drop, pricing pressures mount, and key drug patents expire. Bernstein’s Courtney Breen noted the stock would likely stay stuck in the “mid-20s” range until clearer growth prospects emerge. 5
This sheds light on why traders view vaccine news as a shift in sentiment rather than a straightforward earnings driver. Pfizer does sell vaccines, but it relies heavily on oncology, specialty care, and the Seagen-led portfolio to carry much of the growth load.
The Novavax deal gives Pfizer optionality rather than an immediate revenue boost. Any Matrix‑M-based products still need development, testing, and regulatory approval. Plus, the agreement isn’t exclusive.
On the downside, it’s simple: if policy and messaging dampen vaccination rates for a prolonged period, demand gets tougher to predict, commercial costs climb, and the vaccine sector falls out of favor—even among diversified investors. Since vaccine projects typically stretch over long timelines, the market can start pricing in uncertainty long before any pipeline results emerge.
Before Friday’s session kicks off, investors are eyeing potential new policy moves and gauging if large-cap drugmakers continue to draw relative interest compared to vaccine-focused specialists, which have already experienced more volatile swings around the headlines.
Pfizer’s next major event is its quarterly corporate update on February 3. The company will share results and guidance with analysts at 10:00 a.m. ET, offering a key look at cost controls and how management plans to navigate vaccine demand uncertainty. 6
