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LSE:MPH 30 December 2025

Mereo BioPharma stock crashes 88% after Phase 3 setrusumab miss sinks brittle-bone hopes

Mereo BioPharma stock crashes 88% after Phase 3 setrusumab miss sinks brittle-bone hopes

Mereo BioPharma shares plunged 87.65% to $0.29 after late-stage trials of setrusumab failed to meet the main fracture-rate goal in osteogenesis imperfecta. Both Phase 3 studies missed the primary endpoint, though bone mineral density improved and no new safety issues appeared. Analysts cut ratings as the company moved to reduce spending. Trading volume reached about 241 million shares.
30 December 2025
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Stock Market Today

  • Nasdaq Falls as Super Micro AI Chip Smuggling Charges Hit Market
    March 20, 2026, 12:01 PM EDT. The Nasdaq composite dropped about 1% on March 20, 2026, led by a sharp 28.37% plunge in Super Micro Computer shares following charges against its co-founder for conspiring to smuggle $2.5 billion of Nvidia AI chips to China. The indictment alleges complex export control violations, involving fake shipping documents and label swapping to mask shipments through Southeast Asia. Nvidia shares fell 1.66% given their exposure to Super Micro, and AMD dropped 2.32% amid sector-wide unease. The Invesco QQQ Trust also slipped 1%, extending its four-week losing streak amid ongoing geopolitical strains, including Iran tensions and volatile oil prices. Analysts question Super Micro's credibility and internal controls despite the charges targeting individuals rather than the firm itself.
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