Prelude Therapeutics (PRLD) Stock’s Wild Ride: 150% Surge, Big Pharma Deal & What’s Next

Prelude Therapeutics – a small precision oncology biotech – suddenly became one of the market’s most volatile stocks in early November 2025. On Monday, Nov 3, PRLD shares skyrocketed, at one point gaining over 150%. The stock surged from roughly $1.60 into the $3–4 range, fueled by speculative buzz and unusually heavy tradingrttnews.com. More than 29 million shares changed hands in a single day, and the price hit a 52-week high of $4.19rttnews.com. By the session’s end, Prelude closed near $4 – an astronomical one-day move for a company of its size.