- $12B Takeover Deal: Swiss pharma giant Novartis has agreed to acquire Avidity Biosciences for $72 per share in cash, a ~46% premium over Avidity’s last closing pricereuters.com. The all-cash deal values the RNA-focused biotech at roughly $12 billion and was announced on Sunday, Oct. 26, 2025.
- Stock Surge on News: Avidity’s stock (NASDAQ: RNA) closed around $49.15 on Fridaybusiness-standard.com, and is expected to skyrocket toward the $72 offer price when markets reopen. Shares already jumped on takeover rumors earlier this year – gaining ~26% in one day back in August on initial Novartis speculations1 .
- Rare Disease Pipeline: Novartis is buying Avidity to seize its cutting-edge RNA therapeutics for rare muscle disorders. Avidity’s pipeline includes first-in-class drug candidates for Duchenne muscular dystrophy (DMD), facioscapulohumeral muscular dystrophy (FSHD), and myotonic dystrophy type 1 (DM1)biospace.com. Its lead DMD drug (“del-zota”) showed breakthrough clinical results and is nearing an FDA filing by early 20262 .
- Analyst Buzz & Forecasts: Even before the buyout news, Wall Street was bullish on Avidity – the stock carried a “Moderate Buy” consensus and a 12-month price target around $67–$68 (~38% above last week’s price)marketbeat.com. Back in August, analysts said a Novartis bid was “unconfirmed but reasonable,” citing Avidity’s “leading RNA therapy platform” and a pipeline poised for “multi-billion dollar opportunities” if successfults2.tech. Short interest in RNA had been high (over 14% of sharesmarketbeat.com) but was declining as investor optimism grew.
- Trading Momentum: Avidity’s stock has been on a tear in recent months. It climbed 40%+ in the last quarter alone, hitting a 52-week high of $56 earlier in Octobermarketbeat.comsahmcapital.com. At ~$49 pre-deal, shares were already up over 100% from 52-week lows. Technical indicators have reflected this strength – RNA has been trading above key moving averages amid buyout rumors and trial breakthroughs. With the takeover announcement, traders anticipate the price will stabilize near $72, barring any surprise competing bids or regulatory hurdles.
- Fundamentals & Value: As a clinical-stage biotech, Avidity isn’t profitable yet – its valuation has been driven by future potential rather than current revenues. In fact, one analysis noted RNA’s price-to-book ratio was around 5×, well above the biotech industry average (≈2.2×), suggesting the stock was pricey on fundamentalssahmcapital.com. A Simply Wall St model even estimated Avidity’s fair value closer to $36 per share based on its assets and projected cash flowssahmcapital.com. Novartis’ $72 offer, however, underscores the strategic value of Avidity’s technology – big pharma is clearly willing to pay a hefty premium for its RNA delivery platform and late-stage drug candidates. Avidity’s CEO Sarah Boyce affirmed that the Novartis deal “maximizes value for our investors” and will help “expand our pipeline globally”biospace.com3 .
- Novartis’ Strategy & Biotech M&A Wave: This acquisition is part of a broader biotech buyout boom. Large pharmaceutical companies are racing to buy innovative drugmakers to bolster their pipelines as older drugs face patent expirationsbusiness-standard.com. Novartis in particular has been on a shopping spree in 2025 – earlier this year it snapped up Anthos Therapeutics for $3.1B (cardiovascular drugs) and Regulus Therapeutics for $1.7B (kidney disease)reuters.com. Just last month, Novartis agreed to acquire Tourmaline Bio for ~$1.4Bbusiness-standard.com. Buying Avidity fits this trend, giving Novartis a foothold in RNA-based neuromuscular therapies and a stronger presence in U.S. rare-disease R&Dreuters.com. Analysts note the move mirrors Novartis’ 2024 purchase of Kate Therapeutics, another gene therapy player in neuromuscular diseasereuters.com. In short, big pharma is willing to spend big now to secure the next generation of treatments (and revenue) before patent cliffs hit.
- Competitors & Market Reaction: The Avidity deal also shines a spotlight on its peers in the RNA therapeutics space. Dyne Therapeutics (NASDAQ: DYN) – a rival working on similar muscle-targeted RNA drugs – has seen its stock skyrocket ~75% in the past six months amid positive trial resultsts2.tech. Wall Street is overwhelmingly bullish on Dyne as well, with multiple analysts rating it a Buy and price targets as high as $30–$50 (implying triple-digit upside from recent levels)ts2.tech. This enthusiasm suggests investors view neuromuscular RNA therapies as a breakthrough area. With Avidity getting scooped up at a rich valuation, speculation could turn to whether other biotechs in this niche (like Dyne or Ionis Pharmaceuticals) might be next on the M&A radar. Overall, the Novartis-Avidity news is lifting sentiment across the biotech sector, reinforcing the idea that pharma’s appetite for innovative platforms remains strong.
- What’s Next – Outlook and Risks: Avidity Biosciences shareholders are poised to receive $72 per share in cash when the Novartis acquisition closes, which is expected in the first half of 2026biospace.com. Notably, Avidity will spin off its early-stage cardiology programs into a new publicly traded “SpinCo” before the deal closesbiospace.com. That means investors will likely get shares in this separate cardiac-focused company in addition to the cash payout – effectively unlocking additional value from assets outside Novartis’s purchase. Regulatory approval of the merger is anticipated, as the deal faces little antitrust pushback (Novartis and Avidity have minimal overlap). The main risk would be any unforeseen clinical setbacks in Avidity’s pipeline before closing, but Novartis appears confident – its CEO Vas Narasimhan praised Avidity’s “pioneering [antibody-oligonucleotide] platform” and “potentially first-in-class medicines” for devastating neuromuscular diseasesbiospace.com. For short-term traders, RNA stock will now trade largely on deal arithmetic (likely hovering just below $72, reflecting the time value to closing). Long-term investors should consider that Avidity’s growth story will soon fold into Novartis – meaning future upside will be through owning Novartis (which, conversely, now gains a promising neuromuscular pipeline). Analysts generally view the deal as a win-win: Avidity investors lock in a big premium, and Novartis gains a platform that could yield “multi-billion-dollar” drugs by 20304 .
Bottom Line: Avidity Biosciences’ stock is set to explode higher on Novartis’s $12 billion buyout, capping off a dramatic run fueled by breakthrough science and takeover buzz. The high-premium deal underscores the massive value of RNA therapeutics for rare diseases – and signals that big pharma’s biotech spending spree isn’t slowing down. While Avidity’s chapter as an independent company is closing, its novel treatments may reach patients faster under Novartis’s umbrella. Investors now await the finalization of the deal (and SpinCo details), as Wall Street cheers another biotech success story in the making. 🏥💥
Sources: reuters.comreuters.combusiness-standard.combiospace.combiospace.commarketbeat.comts2.techmarketbeat.comsahmcapital.comsahmcapital.combiospace.combiospace.combusiness-standard.comreuters.combusiness-standard.comreuters.comreuters.comts2.techts2.techbiospace.combiospace.combiospace.com4
