Agios Pharmaceuticals (AGIO) Stock Slides on Mixed Phase 3 Sickle Cell Results From RISE UP Trial
Agios Pharmaceuticals’ Phase 3 RISE UP trial of mitapivat in sickle cell disease met its hemoglobin-response primary endpoint but failed to show a significant reduction in pain crises or fatigue. Shares fell sharply, dropping as much as 50% pre-market before paring losses. The company plans to meet with the FDA in early 2026 to discuss a potential U.S. marketing application.
