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NASDAQ:INCY 4 November 2025 - 8 December 2025

Biggest Stock Losers Today: LEGN, MRVL, UL and More Slide as Wall Street Braces for a Fed Rate Cut (December 8, 2025)

Biggest Stock Losers Today: LEGN, MRVL, UL and More Slide as Wall Street Braces for a Fed Rate Cut (December 8, 2025)

Legend Biotech fell 12.8% to a new 52-week low Monday, leading U.S. stock declines as the S&P 500 hovered just below record highs ahead of the Fed’s rate decision. Marvell Technology dropped 8.6%, Unilever ADR lost 7%, and several others slid 4–6%. Traders priced in an 85–90% chance of a 25-basis-point Fed rate cut this week.
Prelude Therapeutics (PRLD) Stock’s Wild Ride: 150% Surge, Big Pharma Deal & What’s Next

Prelude Therapeutics (PRLD) Stock’s Wild Ride: 150% Surge, Big Pharma Deal & What’s Next

Prelude Therapeutics shares surged over 150% on Nov. 3, then dropped about 40% the next day amid record trading. The swings followed news that Incyte Corp. will pay $60 million upfront for rights to Prelude’s JAK2 inhibitor program, with future payments possible. Prelude is pausing one pipeline program, refocusing on two others, and its Chief Medical Officer has departed. Cash reserves now extend operations into 2027.
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