NYSE:PFE 23 November 2025 - 13 December 2025

Pfizer shares traded near $25.78 early Thursday, flat from Wednesday’s close, after hedge fund Marshall Wace disclosed a 96.8% reduction in its stake. The stock remains over 50% below its December 2021 high. Pfizer’s 52-week range is $20.92 to $27.69, with a market cap near $147 billion and a dividend yield around 6.7%.

Pfizer shares traded near $25.5 on December 10, up less than 1% but still over 50% below their 2021 peak. The company announced a $2.1 billion obesity-drug partnership with China’s YaoPharma, reported Phase 3 wins for TUKYSA and HYMPAVZI, and confirmed new job cuts in Switzerland. Dividend yield stands near 6.7%. Pfizer reaffirmed 2025 adjusted EPS guidance at $3.00–$3.15.

Pfizer closed at $25.74 on Friday, November 28, 2025, with a market cap near $146 billion ahead of Monday’s U.S. market open. The stock has traded above its 50- and 200-day moving averages since early November but remains down 3.1% year-to-date, underperforming the Dow’s 11.5% gain.

Pfizer closed Tuesday at $25.72, up nearly 2%, with a dividend yield of about 6.7% and a market cap near $146 billion. Unusual options activity clustered at the $25 strike followed new FDA approval for PADCEV plus Keytruda in bladder cancer and the completed Metsera obesity drug acquisition. Analyst target averages $28.56. Pfizer trades at a forward P/E of about 8.6, with 2025 total return up 3–4% year-to-date.