Pfizer (NYSE:PFE) climbs 7% after main drugs offset fall in COVID sales

Pfizer (NYSE:PFE) climbs 7% after main drugs offset fall in COVID sales

NEW YORK, August 8, 2026, 16:08 EDT — U.S. markets have closed for the weekend.

  • Pfizer ended the session at $26.76 following six consecutive advances, climbing 7.0% over the last week.
  • Four non-COVID franchises generated $797 million, offsetting the COVID drop by 1.5 times.
  • Analysts’ average price target suggests just 7.0% more upside.

The quarter delivered clear sales support for Pfizer’s weekly upward trend. Four non-COVID segments generated an additional $797 million compared to the previous year. This amount was 1.5 times greater than the total decline seen in Comirnaty and Paxlovid.

Stock chart for NYSE:PFE

This shift is significant, indicating Pfizer is offsetting lost pandemic income rather than just reducing costs. Shares closed at $26.76 on Friday, rising for a sixth consecutive session. The stock is still down 6.9% from its April peak.

Management’s updated guidance aligns with this trend. Non-COVID projections climbed $1.5 billion, while COVID-related forecasts dropped $1 billion. The revenue midpoint was revised up by $500 million to $61.5 billion.

The divergence among peers signals more than just an overall market boost. The weekly shifts below are calculated using closing prices from July 31 and August 7.

SecurityJuly 31 closeAugust 7 closeWeekly move
Pfizer Inc. $25.01$26.76+7.0%
Bristol Myers Squibb Co. $65.31$64.72-0.9%
Merck & Co. Inc. $130.20$128.58-1.2%
S&P 500 Index7,489.727,757.64+3.6%

Pfizer outpaced the S&P 500’s weekly increase, almost doubling it. Major pharmaceutical peers posted declines.

The sales bridge showed concentration. Eliquis accounted for $422 million, making up 53% of the four-franchise rise. This subtotal is derived from Pfizer’s unaudited product data.

Q2 sales bridge2025, $mln2026, $mlnDollar changeReported change
Eliquis2,0032,425+422+21%
Padcev542667+125+23%
Lorbrena251354+103+41%
Vyndaqel family1,6151,762+147+9%
Subtotal for four franchises4,4115,208+797+18.1%
Comirnaty and Paxlovid808282-526-65.1%

The quarter surpassed expectations ahead of the results. Revenue came in roughly $630 million above consensus estimates. Adjusted earnings were nine cents higher than projected. However, the reported earnings were in the red.

Financial measureReported or currentComparatorDifference
Q2 revenue$15.03 bln$14.40 bln consensus+$0.63 bln
Q2 adjusted EPS$0.77$0.68 consensus+$0.09
Q2 reported EPS-$0.04$0.51 year earlier-$0.55
2026 revenue midpoint$61.5 bln$61.0 bln previously+$0.5 bln
2026 adjusted EPS midpoint$2.90$2.90 previouslyNo change

The GAAP loss included $4.3 billion in non-cash impairments. Of that, $3.8 billion was tied to sigvotatug vedotin, which came through the Seagen acquisition. This charge offsets sales gains.

Chief Executive Albert Bourla stated, “We are creating efficiencies … and we reinvest in R&D.” Operationally, adjusted research and development expenses increased by 11% in the first half. Adjusted selling, informational and administrative expenses declined by 4%. Reuters

Pfizer distributed $4.9 billion in dividends over the first half and does not intend to conduct share buybacks in 2026. As of Friday’s close, the indicated yield stood at 6.43%. The dividend continues to be Pfizer’s primary direct shareholder return.

Analysts were divided in their post-earnings calls. The average price target from 28 analysts stood at $28.64, representing a 7.0% premium to Friday’s close. Price targets ranged from $25 to $35.75.

Firm or consensusDateRecommendationTargetImplied move
GuggenheimAug. 7Buy reiterated$31 cut from $35+15.8%
Bernstein Research / AllianceBernstein Holding L.P. Aug. 7Market Perform reiterated$29 trimmed from $30+8.4%
Goldman Sachs Group Inc. Aug. 6Neutral$26-2.8%
Rothschild & Co RedburnAug. 5Neutral$25 up from $24-6.6%
28-analyst consensusAug. 7Outperform$28.64+7.0%

Trung Huynh at RBC Capital, part of Royal Bank of Canada , described the outperformance as broad-based. He noted that investors would require important catalysts in 2026 before assigning a growth-company label again.

Markets reopen on Monday. Upcoming inflation data is the next major focus, with July CPI set for release on Wednesday, PPI on Thursday, and retail sales on Friday.

DateU.S. releaseTime, EDTPreliminary estimate
Wednesday, Aug. 12July CPI08:30Headline rises 3.4% year-on-year; core up 2.5%
Thursday, Aug. 13July PPI08:30No consensus available
Friday, Aug. 14July retail sales08:30No consensus available

Should the CPI come in stronger, Treasury yields might rise, possibly making Pfizer’s 6.43% yield less attractive in comparison. Conversely, a weaker reading may have the opposite effect.

Risks: Pfizer continues to contend with looming patent cliffs, key pipeline updates, and a potential acceleration in the decline of COVID-related sales. The $3.8 billion write-down highlights the risk that purchased assets may underperform. Consensus price targets give scant space for a further 7% rise in the shares this week.

TS2 TECH • EXTENDED COVERAGE

Further analysis

Has Pfizer’s second-quarter outperformance significantly strengthened the company’s 2026 earnings outlook?
Revenue climbed to $15.03 billion, an increase of 3%, and adjusted EPS came in at $0.77. Adjusted EPS exceeded consensus by $0.09 but declined by one cent compared to the prior year. Pfizer lifted its revenue midpoint by $500 million to $61.5 billion, maintaining adjusted EPS guidance at $2.80 to $3.00. Operationally, non-COVID revenue advanced 5%, while COVID-related guidance was lowered by $1 billion. The main business showed gains, but the overall earnings outlook saw little change.
Is the broadened cost initiative able to safeguard margins during periods of patent expirations?
Pfizer aims to achieve around $9.7 billion in net savings by 2029, with the latest phase contributing an additional $2.5 billion starting in 2027. Second-quarter selling and administrative expenses dropped 3% on an operational basis compared to last year. Research and development expenses increased by 12%, primarily due to investments in oncology and obesity projects. However, adjusted earnings per share for the first half were down 10% from the previous year. Pfizer anticipates $1.1 billion in headwinds during 2026 from competition by generics and biosimilars. While cost savings help support margins, new launches are still required to offset declining revenues.
To what extent did the most recent impairment affect the investment outlook for Seagen?
Pfizer reported $4.3 billion in impairments of intangible assets for the second quarter, with $3.8 billion attributed to Seagen’s sigvotatug vedotin program. The charge is significant when compared to Pfizer’s $43 billion acquisition of Seagen. The Phase 3 trial for lung cancer failed to deliver a notable improvement in overall survival. However, operational U.S. revenue from Seagen products rose 21% in the second quarter, while Padcev sales climbed 23% to $667 million in the period. The impairment is substantial, while overall evidence for the acquisition remains mixed.
What pipeline milestones might impact Pfizer's growth prospects in the near term?
The FDA has given priority review to Talzenna combined with Xtandi for HRR-mutated metastatic castration-sensitive prostate cancer. Pfizer anticipates progressing ten pivotal studies for berobenatide in 2026. Data from early-stage amylin monotherapy and from berobenatide combinations is also anticipated in the second half of 2026. In advanced prostate cancer, mevrometostat remains set for a 2026 readout as well. These milestones may back management’s post-2028 growth strategy, though results are still uncertain.
Is Pfizer’s valuation sufficient to reward investors for its execution and balance-sheet risks?
Pfizer shares were at $26.76 on August 7, valuing the company at roughly 9.2 times its midpoint adjusted EPS forecast. The quarterly dividend of $0.43 means an annual yield of about 6.4%. This annualized payout is approximately 59% of the $2.90 adjusted EPS midpoint. Operating cash flow for the first half reached $3.45 billion, compared to $4.90 billion in dividend disbursements. Long-term debt was reported at $60.5 billion, with no share repurchases projected for 2026. Investors receive income from the yield, but leverage and cash generation continue to pose significant risks.
Michał Rogucki

Michał Rogucki is a senior markets reporter at TS2.tech, specializing in stocks, technology and macroeconomic developments. A graduate of Humboldt University of Berlin, he previously worked in investment research and market analysis before transitioning to financial journalism. He covers the trends and events that matter most to investors worldwide.

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