Praxis Precision Medicines (PRAX) Stock Skyrockets 180% on Game‑Changing Trial – Analysts See ‘Blockbuster’ Upside
Praxis Precision Medicines shares skyrocketed on October 16, 2025, after the biotech reported game-changing Phase 3 trial results for its essential tremor drug. The stock closed that Thursday at $162.71, up over 183% in a single daymedcitynews.com. Earlier that morning, Praxis announced that ulixacaltamide – its experimental therapy for essential tremor – had succeeded in two pivotal late-stage studies. The news sent PRAX stock soaring more than threefold before the opening bellreuters.comreuters.com, smashing its previous highs. By midday, Reuters estimated Praxis was on track to add about $2.67 billion to its market capitalization if gains heldreuters.com. The rally gave the company a market value near $4 billion, up from roughly $1 billion just a day prior. What drove this explosive surge? In a word: breakthrough efficacy. Praxis’s Phase 3 program tested ulixacaltamide in adults with essential tremor – a neurological disorder causing involuntary shaking. In the first trial, ulixacaltamide patients showed a 4.3-point improvement on a standard daily living scale versus placeboglobenewswire.comglobenewswire.com, a highly significant gain. All key secondary endpoints were also metglobenewswire.com, indicating improvements in disease severity and patient and clinician impressions. A second trial used a randomized withdrawal design, and it too succeeded: 55% of those who stayed